Chlorophyllin's Surprising Health Potential—From Anaemia to Acne and Beyond
Chlorophyll, the green pigment essential for plant photosynthesis, has drawn interest for its possible health benefits in humans. Researchers have explored its effects on wounds, skin conditions, and even weight loss. A related compound, chlorophyllin, has been studied in supplements and medical treatments with mixed results. Chlorophyllin is a semi-synthetic form of chlorophyll, made by replacing its magnesium with copper. For decades, studies have found no serious toxicity from its use in humans. Cleveland Clinic researchers confirmed its safety in moderation, though mild side effects like stomach discomfort, green-tinged stool, or increased sunburn risk can occur.
Four key human trials in the last ten years examined chlorophyllin's effects. A 2019 Chinese study on iron-deficiency anaemia showed it raised red blood cell and haemoglobin levels. Two separate acne studies—one testing topical chlorophyllin alone, another combining it with light therapy—focused on participants with darker skin types. Most recently, the 2022 CLARITY trial tested chlorophyllin on 24 patients with radiation-induced bladder bleeding, achieving a 70.8% response rate. Beyond wound healing and skin improvements, some evidence suggests chlorophyll may ease inflammation in conditions like inflammatory bowel disease (IBD). One trial also linked a green plant membrane supplement containing chlorophyll to greater weight loss. However, registered dietitian Beth Czerwony advises against chlorophyll supplements, citing insufficient proof of benefit.
While chlorophyllin shows promise in specific areas like anaemia, acne, and bladder damage, experts remain cautious. Its long-term safety record contrasts with limited high-quality evidence for most uses. For now, medical guidance still favours proven treatments over untested chlorophyll-based alternatives.
