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EU Reviews Iron (II) Betaine Complex as New Feed Additive for Livestock

Could this iron-rich additive transform livestock nutrition? Scientists debate analytical methods as the EU weighs approval for a betaine-boosted iron supplement.

The image shows a poster with a bottle of Cebion Merck Vitamin C and a box of pills on it. The...
The image shows a poster with a bottle of Cebion Merck Vitamin C and a box of pills on it. The poster also has text written on it, likely describing the product.

EU Reviews Iron (II) Betaine Complex as New Feed Additive for Livestock

An authorisation request has been submitted for iron (II) betaine complex as a nutritional feed additive. The application covers its use across all animal species and categories. The product contains at least 14% iron and 36% betaine by weight as its primary components. The Applicant proposed several analytical methods for verifying the additive’s composition. For total iron in the feed additive itself, they suggested EN 15621. The European Union Reference Laboratory (EURL), however, recommended three approaches: EN 15621, EN 15510, and ISO 6869. For premixtures and compound feed, the EURL favoured EN 17053 over the Applicant’s EN 15621 method.

To quantify betaine, the Applicant put forward the ICUMSA method using HPLC-RI. The EURL supported this choice, confirming HPLC-RI as the preferred technique. Additionally, the EURL approved X-ray diffraction (XRD) as a reliable way to confirm the formation of the iron (II) betaine complex.

The proposed iron levels in compound feed range between 450 and 750 mg per kilogram. The recommended iron analysis methods for the additive include inductively coupled plasma atomic emission spectroscopy (ICP-AES) under EN 15621 or EN 15510, or atomic absorption spectroscopy (AAS) as per ISO 6869. The authorisation request outlines specific analytical techniques for both iron and betaine content. If approved, the additive would be used in feed formulations with iron concentrations of 450 to 750 mg/kg. The EURL’s recommendations provide a standardised approach for verifying its composition and structure.

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