Fisetin and NAD+: A Senolytic Approach to Supporting Brain Longevity
New research highlights the potential of fisetin, a natural compound found in fruits and vegetables, to support brain health as we age. Scientists are exploring how it interacts with NAD+, a molecule vital for cellular energy and repair. Early findings suggest fisetin may help maintain a healthier cellular environment by targeting problematic cells and reducing inflammation.
NAD+ plays a key role in keeping the brain functioning well. It supports neurons and other brain cells in their daily tasks, from sending signals to managing repairs. But as people get older, NAD+ levels naturally drop due to slower production and higher demand from enzymes like CD38, which become more active with age and inflammation.
One factor in this decline is the buildup of senescent cells—cells that no longer work properly but remain metabolically active. These cells release inflammatory signals, further straining NAD+ supplies. Fisetin, a flavonoid studied in senolytic research, may help by selectively targeting these cells under certain conditions. Preclinical studies have shown fisetin’s potential in reducing the effects of stroke, mild cognitive impairment, and dementia. While its direct impact on NAD+ in brain ageing is still being investigated, researchers note its broader benefits for cellular health. Some longevity routines now include fisetin either as a regular supplement or in short, concentrated doses—a method called 'pulsing'—to support NAD+ balance. To track progress, NAD+ testing can measure how well fisetin or similar strategies work. By establishing a baseline and retesting after consistent use, individuals can assess changes in their cellular health over time.
Fisetin’s ability to target senescent cells and reduce inflammation could make it a useful tool in supporting brain health. While more research is needed on its direct effects on NAD+ levels, current evidence points to its broader role in maintaining cellular function. Testing and tailored routines may help individuals monitor its impact as part of a long-term health strategy.
