Portugal's First Non-Invasive Brain Therapy for Maternal Depression Launches in Coimbra
A new, non-invasive treatment for perinatal depression is being introduced in Portugal for the first time. The approach combines brain stimulation with app-based psychological support and is now available at Coimbra's Bissaya Barreto General Hospital. Researchers from the University of Coimbra are leading the initiative as part of the 4MUMs project.
The treatment merges low-intensity transcranial direct current stimulation (tDCS) with cognitive-behavioural exercises delivered through a mobile app. TDCS is a safe, drug-free method that gently alters brain activity to improve mood and function. Over ten weeks, participants receive targeted brain stimulation alongside guided psychological sessions.
Staff at the maternity hospital have undergone specialised training to deliver the program. A focus group study was also conducted to refine the approach before its rollout. The intervention has already shown promise in the UK, where women reported better mood, reduced depressive symptoms, improved sleep, and enhanced well-being.
Currently, 40 pregnant women or those in the postpartum period will take part in an observational study. While this trial does not yet have published results, earlier research on GLP-1 drugs for idiopathic intracranial hypertension (IIH) in over 1,100 patients suggested significant benefits—such as fewer headaches, less vision loss, and reduced need for surgical interventions. However, these findings relate to a different condition and treatment method.
Francisco Maio Matos, president of Coimbra's Local Health Unit, highlighted the growing urgency of addressing maternal mental health. Coimbra's expertise in this area has positioned it as a key reference centre for such innovations.
The program is now accessible at Bissaya Barreto General Hospital under the 4MUMs project. If successful, it could offer a drug-free alternative for managing perinatal depression. The study's outcomes will help determine its broader application in maternal healthcare.
