Potential Adverse Reactions of Uceris and Strategies for Coping with Them
Uceris, a brand-name drug prescribed for ulcerative colitis in adults, can provide relief for those suffering from the condition. However, like many medications, Uceris comes with potential side effects and risks that patients should be aware of.
One of the primary concerns with Uceris is its impact on the immune system. The drug may increase the risk of infection, including severe measles and chickenpox. Therefore, it's crucial to inform your doctor if you have an active or chronic infection before starting Uceris treatment. This is because Uceris can weaken your immune system, making you more susceptible to infections.
Common side effects of Uceris include headache, nausea, fatigue, abdominal pain, joint pain, bloating, acne, gas, urinary tract infection (UTI), constipation, and decreased cortisol levels. Symptoms of an infection may include fatigue, sore throat, fever, skin rash, joint or muscle aches, runny nose, and cough. If you develop such symptoms while using Uceris, contact your doctor right away.
Long-term use of Uceris can suppress natural cortisol production and adrenal function, leading to conditions like hypothalamic-pituitary-adrenal (HPA) axis suppression and adrenal insufficiency. These conditions may cause symptoms such as tiredness, weakness, nausea, vomiting, and low blood pressure. It's important to note that treatment with Uceris is generally short-term, usually lasting 6–8 weeks, to induce remission in mild to moderate ulcerative colitis. This limits the risk of long-term adverse effects related to cortisol suppression.
However, if Uceris is used for longer periods or at higher doses, careful monitoring for symptoms of adrenal insufficiency and gradual dose tapering are essential to reduce adverse consequences.
Uceris may also lead to other long-term complications. For instance, it can cause osteoporosis due to low bone mineral density, especially with long-term use. Additionally, long-term use of Uceris can worsen certain eye conditions, such as glaucoma or cataracts.
Before starting Uceris treatment, inform your doctor about any pre-existing conditions, such as high blood pressure, diabetes, liver problems, glaucoma or cataracts, osteoporosis, or a history of low bone density. Also, if you have an active infection or a history of chronic or recurring infections such as tuberculosis, it's important to disclose this information to your doctor.
If you're planning to have surgery, inform your care team about every medication you take, including Uceris, as it may affect your response to stressful situations, including surgery.
It's also worth noting that Uceris may increase your blood pressure, especially if taken long term, and may make it more difficult to manage diabetes. Extra safety precautions should be taken around people who may have an active infection while using Uceris.
In rare cases, mild allergic reactions are possible after using Uceris, although this side effect wasn't reported in clinical trials. If you experience any allergic reaction, consult your doctor immediately.
The Food and Drug Administration (FDA) tracks and reviews side effects of medications like Uceris, and you can report side effects to them through MedWatch.
In summary, Uceris can provide relief for ulcerative colitis patients, but it's essential to be aware of the potential risks and side effects, especially with long-term use. Always consult your doctor about any concerns or questions you may have regarding Uceris treatment.
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