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Why Stopping Tirzepatide Suddenly Could Backfire on Weight Loss

The price of Tirzepatide is pushing users to quit—but stopping cold turkey could undo months of progress. Here’s what happens when the drug wears off.

In this image I can see the person's photo. To the side of the photo I can see many bottles and few...
In this image I can see the person's photo. To the side of the photo I can see many bottles and few pills in it.

Why Stopping Tirzepatide Suddenly Could Backfire on Weight Loss

The weight loss drug Tirzepatide (Mounjaro), a weekly injection, was originally developed for long-term metabolic health rather than quick fixes. But as costs rise and users reconsider treatment, stopping the medication safely has become a growing concern. Without proper guidance, quitting abruptly can lead to unwanted side effects and rapid weight regain.

Tirzepatide works best when used continuously, and halting treatment often results in significant weight rebound. Studies show that those who stop typically regain weight in proportion to their initial loss. For example, Gillian, a former user, saw cravings return and her weight climb after discontinuing the drug due to a steep price hike.

Tirzepatide’s rising price has forced some users to reconsider their options, but quitting without medical advice carries risks. Gradual tapering, dose adjustments, or switching medications can help manage the transition. Without ongoing lifestyle changes, however, weight regain remains likely for those who stop treatment.

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