New gut-brain hormone reveals how animals crave protein when starved
Scientists have uncovered a new gut-brain connection that controls how animals seek out protein when their diet lacks essential nutrients. The discovery, led by Director Seong-Bae Suh at the Institute for Basic Science (IBS), reveals a hormone called CNMa that signals the brain to prioritise protein-rich foods. This mechanism appears to be shared across species, from flies to mammals. The research focused on Drosophila melanogaster, the common fruit fly, to map how the gut detects a shortage of essential amino acids. When protein levels drop, gut epithelial cells release CNMa, a peptide hormone that activates neurons in the digestive system. This signal travels to the brain, where it influences feeding behaviour and increases the drive to consume protein.
The gut itself acts as a sensory organ, constantly monitoring nutrient levels and relaying deficiencies to the central nervous system. The brain then adjusts eating habits to correct imbalances, ensuring survival. Experiments showed that CNMa works on specific brain circuits, reinforcing the preference for protein-heavy meals.
Interestingly, the gut’s microbiome plays a role in regulating this process. Flies without natural microbial populations displayed stronger activation in amino acid-sensitive neurons, suggesting bacteria help fine-tune the body’s response to dietary needs.
To confirm the findings, researchers tested the same mechanism in mice. The results indicated that CNMa’s role in gut-brain communication is evolutionarily conserved, meaning it functions similarly across different species. The study highlights how the gut and brain work together to maintain nutritional balance, particularly for protein. By identifying CNMa as a key hormone in this process, the research opens doors for understanding how animals—including humans—adapt their diets to survive. The findings also suggest potential links between gut bacteria, nutrient sensing, and eating behaviours.
Read also:
- Solingen's Glass Workshop Hosts Free Health Day with Expert Talks and Wellness Activities
- Persimmon farming booms in India as farmers ditch apples for higher profits
- Fresh Bellies Thrives After Shark Tank Rejection With $6M in Sales
- California Walnuts Shine as a Heart-Healthy Superfood This Nutrition Month
